Milan Stefek Selected Research

Aldehyde Reductase (Aldose Reductase)

5/2021	Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications.
4/2021	Combatting Nitrosative Stress and Inflammation with Novel Substituted Triazinoindole Inhibitors of Aldose Reductase in PC12 Cells Exposed to 6-Hydroxydopamine Plus High Glucose.
1/2021	Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis.
1/2020	Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat-another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats.
5/2019	3-Mercapto-5H-1,2,4-Triazino[5,6-b]Indole-5-Acetic Acid (Cemtirestat) Alleviates Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats: A Role of Aldose Reductase.
4/2017	Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation.
3/2017	Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases.
1/2016	Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins.
4/2014	Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation.
3/2012	Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts.

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Milan Stefek Research Topics

Disease

13	Diabetes Complications 05/2021 - 05/2008
10	Hyperglycemia 01/2020 - 10/2002
5	Inflammation (Inflammations) 04/2021 - 02/2015
5	Body Weight (Weight, Body) 01/2020 - 01/2002
5	Cataract (Cataracts) 01/2016 - 01/2005
4	Neoplasms (Cancer) 12/2017 - 01/2016
4	Hemolysis 01/2015 - 01/2010
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 05/2019
1	Parkinson Disease (Parkinson's Disease) 04/2021
1	Diabetes Mellitus 04/2021
1	Sepsis (Septicemia) 01/2021
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2020
1	Diabetic Neuropathies (Diabetic Neuropathy) 05/2019
1	Colorectal Neoplasms (Colorectal Cancer) 12/2017
1	Carcinogenesis 01/2016
1	Colitis 01/2016
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2010
1	Mastocytoma 09/2007
1	Diabetic Retinopathy (Retinopathy, Diabetic) 07/2007
1	Reperfusion Injury 03/2007

Drug/Important Bio-Agent (IBA)

15	Aldehyde Reductase (Aldose Reductase)IBA 05/2021 - 05/2008
9	AntioxidantsIBA 05/2021 - 06/2003
8	dicarbineIBA 07/2011 - 01/2004
7	polyolIBA 05/2021 - 12/2009
6	EnzymesIBA 05/2021 - 05/2008
6	Glucose (Dextrose)FDA LinkGeneric 04/2021 - 01/2002
5	Free RadicalsIBA 01/2015 - 01/2005
4	Vitamin E FDA LinkGeneric 07/2007 - 10/2002
3	Sorbitol (Yal)FDA Link 01/2020 - 01/2016
3	Acetic Acid (Vinegar)FDA LinkGeneric 05/2019 - 01/2016
3	Proteins (Proteins, Gene)FDA Link 03/2017 - 01/2005
3	FlavonoidsIBA 02/2015 - 06/2011
2	indoleIBA 05/2021 - 05/2019
2	cemtirestatIBA 01/2020 - 05/2019
2	SMe1EC2IBA 12/2017 - 01/2013
2	Pharmaceutical PreparationsIBA 01/2016 - 01/2016
2	2,2'-azobis(2-amidinopropane) (ABAP)IBA 12/2011 - 01/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2005 - 10/2002
1	Blood Glucose (Blood Sugar)IBA 04/2021
1	Oxidopamine (6 Hydroxydopamine)IBA 04/2021
1	benzothiazoleIBA 01/2021
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	Streptozocin (Streptozotocin)FDA Link 01/2020
1	Thiobarbituric Acid Reactive SubstancesIBA 05/2019
1	Oxidoreductases (Dehydrogenase)IBA 12/2017
1	ProteomeIBA 12/2017
1	Aldo-Keto ReductasesIBA 12/2017
1	RNA (Ribonucleic Acid)IBA 12/2017
1	diphenyl (biphenyl)IBA 03/2017
1	Sulfhydryl Compounds (Thiols)IBA 03/2017
1	GlucosidasesIBA 03/2017
1	Peroxynitrous Acid (Peroxynitrite)IBA 03/2017
1	NaphthoquinonesIBA 01/2016
1	Alprostadil (Muse)FDA LinkGeneric 01/2016
1	prostaglandin A1 (PGA1)IBA 01/2016
1	epalrestatIBA 01/2016
1	Therapeutic UsesIBA 03/2012
1	SolutionsIBA 12/2011
1	QuercetinIBA 10/2011
1	CalpainIBA 10/2011
1	Peptide Hydrolases (Proteases)FDA Link 10/2011
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 01/2010
1	Caspase 9IBA 09/2007
1	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2007
1	Retinaldehyde (Retinal)IBA 07/2007
1	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)IBA 08/2005
1	polyacrylamideIBA 08/2005
1	Butylated Hydroxytoluene (BHT)IBA 01/2005
1	CalciumIBA 10/2002
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2002

Therapy/Procedure

1	Therapeutics 01/2010
1	Glycemic Control 07/2007